課程資訊
課程名稱
免疫媒介病毒性疾病
IMMUNE MEDIATED VIRAL DISEASES:FROM THEORY TO THERAPY 
開課學期
99-1 
授課對象
生物資源暨農學院  獸醫學研究所  
授課教師
闕玲玲 
課號
VM7088 
課程識別碼
629 M2560 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期三2,3,4(9:10~12:10) 
上課地點
 
備註
上課地點於獸二館709。
限碩士班以上
總人數上限:10人 
 
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課程概述

Unlike most of the viral diseases that can be controlled or eradicated as long as effective vaccines are available, immune mediated viral diseases, as the name implied are diseases that can’t be controlled through vaccination & hence often fetal. This course begin with a general introduction of viral pathogenesis follow by the host immune responses, mechanisms of virus-induced immunopathology, and finally into the possible therapy. Lectures, intensive paper reading, presentation and discussion will all be included in the course.

Lectures:
Part I Essentials of viral pathogenesis
1. The sequential steps in viral infection
2. Cellular receptors & vial tropism
3. Virus-cell interactions
4. Virus-host interactions
Part II Host responses to viral infection
1. Innate response to viral infection
2. Immune responses to viral infection
Part III Mechanisms of virus-induced immunopathology
1. Cell-mediated immunopathology
2. Antibody-mediated immunopathology
3. Virus-initiated autoimmunity
Part IIII Antiviral therapy
1. Classes of antiviral drugs
2. Concepts of therapy for RNA viruses
3. Concepts of therapy for DNA viruses
4. New concepts of antiviral therapy

Journal presentation & discussion:
The main focus of presentation & discussion will be on the current research findings concerning the mechanism and therapy of individual immune-mediated viral disease of animals or human.
 

課程目標
This course aims to introduce basic theory underlying the immune mediated viral disease as well as antiviral therapy currently in use. On the basis of the necessary knowledge students are then requested to read & present articles related to any of the immune mediated viral diseases. Through intensive reading & discussion students are expected to gain a thorough understanding of the disease mechanism, possible therapy dealing with particular disease as well as to establish the ability to critically evaluate and interpret published research articles at the end of the course. 
課程要求
第一堂課準時出席者方取得選修資格 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
 
參考書目
Books:
1. Nathanson N, et al. 2007. Viral pathogenesis and immunity. 2nd edi. Elsevier Ltd.
2. Bogner E, Holzenburg. 2006. New concepts of antiviral therapy. Springer Verlag.
3. Boucher CAB, Galasso GJ, et al. 2002. Practical guidelines in antiviral therapy. Elsevier Science.
4. Shurin MR, et al. 2007. Immune mediated diseases. Advances in Experimental Medicine and Biology, Vol. 601. Springer.
5. Knipe DM, Howley PM. 2007. Fields’ Virology. 5th edi. Lippincott Williams & Wilkins.
Journals: Current articles related to the course from Journals of Virology, Antiviral Therapy, Molecular Medicine, Immunology, Pathology, Veterinary Medicine etc…..
 
評量方式
(僅供參考)
   
課程進度
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日期
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